#035: July 6th, 2021 - Longevity Marketcap Telemetry

On Deck Longevity Biotech. VitaDAO raise. Insilico Medicine, Continuum Biosciences, Vita Therapeutics. Mystery non-profit. Adventures in longevity.

  1. Announcements

  2. Last Week(s) in Longevity

  3. Longevity Futures

  4. Capital Raise Radar

  5. Longevity Jobs

  6. New Companies on Longevity List 

  7. Adventures in Longevity

  8. My Links

*Disclaimer: None of this should be taken as financial advice. It is for educational purposes only.

*Error bounty: Found a factual error in the newsletter? Email me to receive up to $5 in BTC or ETH (pending network conditions, size of error).

Mission: To grow a wave of passionate people building, funding, and championing technologies that extend healthy human lifespan. 

If you want to be part of this mission alongside me, please consider supporting through Patreon or Longevity List Merch.

📢 Announcements 

  • I’ve joined On Deck as Program Director for their Longevity Biotech Fellowship. After working every day, night, and weekend straight, we launched the program last Tuesday. The launch was an incredible success thanks to the amazing Founding Fellows and speakers of the program, the On Deck team, my awesome program partner Ada Nguyen -- and this super epic tweetstorm by Balaji Srinivasan.

    • Why: We need more people working on longevity, especially founders! So we are doing something about it.

    • Mission: On Deck Longevity Biotech (ODLB) has a simple mission: To increase the number of people working to build longevity biotech companies.

    • Who: The fellowship program takes in people who want to DO something about the problem of aging: Founders, aspiring founders, operators looking to join a startup, or investors, regardless of whether you have the “right” background or not. (See Ben Kamens, Matt Scholz, Reason, etc for examples)

    • What: ODLB is a continuous community program that runs year-long with workshops, deep dives with industry experts, 1:1 mentorship, curated connections, social & networking events, and some exciting in-person events post-COVID.

    • When: The deadline for applications for the first cohort is August 31st. Applicants will be accepted on a rolling basis so applying earlier will increase your chances of securing a spot. The first cohort kicks off on September 12th.

    • Cost: Academic pricing is available. Financing plans are available. There are scholarships from On Deck’s Access Fund, too. I will be funding several scholarships out of my own pocket.

      • We’re committed to ensuring that any talented person who deserves to get into the program can do so regardless of their financial situation.

    • Personal note: I already had my hands full with my other longevity projects and have always been a solo entrepreneur. But I decided to join the team at On Deck anyway because I really believed that this program needed to exist. We have the opportunity to make a big impact on human longevity and age-related disease through this fellowship so I encourage anyone who wants to DO something about aging to apply.


đź“ť Last Week(s) in Longevity 

Errata: The original version of the previous newsletter incorrectly stated that Rubedo Life Science’s lead program was a “galacto-conjugate prodrug”. This has been corrected to “prodrug”.

đź“… Longevity Futures

Know of any interesting longevity talks, meetings, or events? Please email me.


📡 Capital Raise Radar

I do not endorse or have affiliations with any of the companies listed below. This is not an offer to buy or sell securities. This is for informational purposes only. If you have intel on any other longevity companies currently raising please email me. It’s free.

  • Stealth synbio & gut microbiome longevity company // Pre-seed // email for details

    • 2nd-time biotech founder

    • Novel synbio approach to longevity, not publicly disclosed

    • Looking to raise a pre-seed round

    • Contact for more details.

  • Protein-based therapeutics for tissue regeneration startup // Series A // email me for more details

    • Proprietary protein library

    • Machine learning-enhanced drug discovery platform 

    • Pipeline of novel drug candidates

    • Contact for more details

  • Stealth reprogramming startup // Seed // email for details

    • Not publicly disclosed. 

    • Contact for more details. 

  • Rubedo Life Sciences // Series A // mentioned on The Longevity Biotech Show

    • Raising Series A in the very near future.

    • Developing a drug discovery platform first focussing on prodrugs to target senescent cells in a selective manner.

    • Team: Marco Quarta (Stanford), Julian Klein, Marc Gallop

  • Yuva Biosciences // Currently raised $1.75M already (Seed) // Article

    • Developing compounds that target mitochondrial dysfunction to reverse aging. Includes natural compound cosmeceutical for skin aging and hair loss. Also developing pharmaceuticals for prostate / ovarian conditions.

    • Team: Keshav Singh (University of Alabama), Greg Schmergel (Nantero)

  • Oncolife Therapeutics // Raising $2M - $3M // Slide deck

    • Developing drugs that modulate stem cell activity to treat cancer and aging

    • Team: Guy Barry (QIMR Berghofer Medical Research Institute, Brisbane, Australia), Paul Baldock (The Garvan Institute of Medical Research, Sydney, Australia)

  • Gerostate Alpha // Raising $500k // WeFunder page

    • High-throughput phenotypic screen platform to discover anti-aging drugs.

    • A spinout from the Buck Institute for Aging. Y Combinator-backed startup.

    • Team includes academics from the Buck Institute: Simon Melov, Mark Lucanic, Gordon Lithgow. 

    • Crowdfunding on WeFunder. Open to all investors, even retail.

    • Already raised $2.1M on a $15M valuation.

  • Ponce de Leon Health // Raising $15M // Article

  • Revivo Therapeutics// Raising: $5M // Slide Deck

    • Small molecule drugs that enhance cognition and reduce neuron excitability to treat neurodegenerative and CNS conditions (including anxiety and depression). 

    • Targets the nitric oxide and CREB pathways. 

    • Same team that built Cardioxyl ($2B exit to Bristol Myers Squib)

  • Equator Therapeutics// Raising: $3M - $5M // Slide Deck

    • Mitochondrial uncoupler drug to burn fat through natural body heat production.

    • Targeting obesity, type 2 diabetes, fatty liver disease, PCOS. 

    • Pro longevity: Exercise mimetic, increases mitochondrial biogenesis, etc

    • Y Combinator-backed company. 

    • Team: Jonah Sinick, Yuriy Kirichok, Michael Grabe, Liliya Gabelev, David Segura 

  • + see all (click on “Capital Raise Radar”)


✨ Featured Longevity Jobs

Looking for jobs, companies, or investors in the longevity biotechnology industry? Check out my website LongevityList.com.

If you are hiring, email me a link to your job postings and I will post them on longevitylist.com (it’s free).


âž• New Companies on Longevity List

Some interesting longevity companies I have stumbled upon and added to the Longevity List database in the past week. Have any longevity company tips? Please email me. 

  • Yap Therapeutics - A spinout from the Texas Heart Institute, this company is developing a gene therapy to modulate the Hippo pathway to induce regeneration of cardiac myocytes after heart attack.  

  • Bit Bio - A Cambridge University spinout founded by Mark Kotter and Florian Schuster. The company is developing a precision reprogramming technology to create any cell type at scale. Initially, they will produce cells for research (in vitro studies, organoids) with possible future development of therapeutics. Investors include Rick Klausner and ARCH Venture Partners.  

  • MetroBiotech - A David Sinclair company developing NAD+ boosting drugs. A clinical trial in partnership with the US military is planned for next year.

  • Nanotics - A company developing a platform of artificial nano-scavengers capable of degrading specific signaling molecules in the blood.


Adventures in Longevity

I’ve been working full-time doing what I can to accelerate progress in longevity for just under a year now. 

In that time, I’ve started a longevity investing newsletter, jobs board, industry database, podcast, longevity biotech stock tracker, clinical trial tracker, mega longevity panel discussion series, venture fund, dabbled in longevity streetwear, made my first angel investment in a longevity company, met (virtually) many of my heroes, made so many new friends in longevity who have helped me along the way, and taken on the responsibility of Program Director for the Longevity Biotech Fellowship at On Deck.

And yes, some longevity memes were also made. (Exhibit A, B, C, D).

My relatively short but surprising adventure in longevity thus far reminds me of something Marc Andreesen wrote: 

“The world is a very malleable place. If you know what you want, and you go for it with maximum energy and drive and passion, the world will often reconfigure itself around you much more quickly and easily than you would think.”

I definitely believe this to be true — and in longevity especially, people are willing to help others who put in the effort.

There are two important keywords here, though:

Passion. How do people know if you are really passionate about something, like longevity? As readers of Kundera’s The Unbearable Lightness of Being1 would know, the word passion comes from the Latin root for “pain”. I know founders in this space that faced rejection after rejection from investors. Those who watched as their peers climbed career ladders while struggling with their own startup. Be aware that the path is often very painful and failure is common.

Go. Aging is a problem of the highest urgency and highest unmet need. 100,000+ people die of age-related diseases every day. The manner of decline and suffering associated with aging is inhumane for many -- and unfortunately, it’s in the cards for everyone if nothing is done about it. We need those who recognize the scale of the problem of biological aging to go take action today.

If you have been on the fence about getting involved in longevity consider taking the leap. There is capital flowing into the space and a lot more is on the way. There are a number of requests for startups from knowledgeable leaders in the field. There are programs to support longevity founders and operators (like the one I am organizing at On Deck).

All we need now is passionate people to go out there and meet the challenge of aging head-on. 

-NATHAN


My Links

Some of my projects, resources, and ways to support my mission. More projects coming…

Projects

  • On Deck Longevity Biotech Fellowship (Program Director)- On Deck Longevity Biotech (ODLB) is a continuous community for people to come together to build, join, or invest in revolutionary longevity biotechnology startups.

  • Healthspan Capital - An early-stage longevity biotech venture fund.

  • Longevity List  - Find jobs, companies, and investors in the longevity industry. Email me if you want to add your job or company to the list. It’s free.

    • Longevity List Database- A handy Airtable base covering people, companies, trials, academic labs, and a list of longevity companies that are presently raising capital.

  • LMC Clinical Trial Tracker- Longevity therapeutics in clinical trials. Completion calendar useful for investors who want to time data readout catalysts.

  • LongevityMarketcap.com- The main page tracks prices of publicly traded longevity stocks.

  • The Future of Longevity- A monthly series of public Q&As in themes and trends with experts in longevity science and industry. Co-hosted by Laura Minquini, Avi Roy, and me. 

  • Longevity Biotech Show - Official website of the Clubhouse show / podcast. We interview the people building, funding, and championing technologies that extend healthy human lifespan. On Clubhouse / Spotify podcasts. 

  • forum.longevitybase.org - An open question and answer system for aging biology and longevity biotechnology. 

  • The One Percent Bet for Longevity Pledge - An initiative to get individuals and corporations to pledge at least 1% of their resources to fund longevity companies and research.

  • LongevityBase.org -  An open-source volunteer initiative to itemize every instance of modulation of biological aging in the scientific literature.

  • Humans for Longevity - A literary art project featuring the stories and motivations behind the people working on solving the problem of aging. 

Support

A special thanks to my Patreon supporters who have joined forces with me to undertake this mission.

1

This is by far my favorite novel.